acetylation of amines with acetic anhydride mechanism

R' N R" O R CH3 O acetyl group Note: R' x��=�r����?��%OE��>s+�*y����I,'�R9y�%ZR"���8���^��3��p��*�@7zG�\ߞ�Y�V��p{�8:]W��Z]������r��������lu�x����Z.���_|Q=z���ღn�_���j*׹ZW�Uu�������Wu����W��*���՛�4n*� �� It often comprises introducing an acetyl functional group in an acidic base to undergo replacement of the hydroxyl group. The resulting positive charge is relayed to the adjacent carbonyl carbon, which binds itself to the phenolic hydroxy group. Your email address will not be published. This acetate ion goes on to associate with the proton liberated by the phenolic OH group (hydroxy group) of the salicylic acid molecule, resulting in the formation of acetic acid (CH3COOH). These are instrumental in drug biotransformation that involves the ways the body processes and excretes drugs, with the help of acetylation reaction. <>>> ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. N-terminal acetylation, which is a very common type of co-transitional covalent modification of proteins, especially in eukaryotes. A blue-green color in the flame indicates the presence of a halogen. 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